He's another thought. gcscott01 states in Post #1 that he used a 4 GiB card for his update to 4.6 and he also used a 4 GiB card for the 4.5 update. See here: [Only registered and activated users can see links. ]. Garmin fw versions are always cumulative not progressive, but if a version earlier than 4.5 enables the unit to read a card larger than 2 GiB then it would explain the 'Unable to read CF card' message if a fw earlier than that one was on the unit. Just a shot in the dark, but if that's the case it should update ok using a 2 Gib card, and you could also try to do it progressively, >4.50>4.60. Good luck, looking forward to your report.
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