Medion devices produced end 2011 and later cannot use TMC using non-GoPal software as there is no proper Primo driver for the TMC chipset (Amaryllo) that supports Primo. Or for Primo that supports the Amaryllo chipset. Whatever is the correct explanation. It won't work. Period.
AFAIK, many tried, none succeeded.

Navigon software could work with a certain programming trick, but I can't say all Navigon software could and which build/version. Maybe your German forum has the info when you want to test Navigon?