Yes, it can happen. I recall a Sandisk 2GB card which i used for backup of 41 for numerous units only to have it baulk on backing up a 2 series nuvi [a 255W i think is my recollection, and it wouldn't recognise the SD at all] after it had been used for other very closely related units. Used a different card and it worked fine.

Interesting that the Transcend worked when the new Kingston froze the unit. Sandisk and Kingston are the only two brands endorsed by Garmin for use of additional map data.